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POST-DOCTORAL FELLOWSHIP – Johns Hopkins University

POST-DOCTORAL FELLOWSHIP POSITION AVAILABLE in the Johns Hopkins University School of Medicine, Department of Dermatology

Name of the Principal Investigator: Nathan K. Archer, Ph.D., Assistant Professor of Dermatology.

Description: Full-time position for a Ph.D. or Ph.D. candidate is available for immunology research in the Johns Hopkins Department of Dermatology to investigate mechanisms of protective innate, antibody, and T cell immunity in host defense against Staphylococcus aureus and MRSA infections. We have made seminal contributions into IL-17 producing T cells and mechanisms of inflammasome activation in both innate and adaptive immune mechanisms in the skin using innovative in vivo preclinical models. Our research employs advanced techniques of in vivo whole animal optical imaging (bioluminescence and fluorescence), human skin organotypic culture models of infection, novel humanized mouse models possessing both human skin and immune cells, multi-parametric flow cytometry, immunofluorescence histology, and RNAseq to interrogate the immune mechanisms in the skin. It is our long-term goal to investigate mechanisms of protective immune responses against S. aureus/MRSA infections to provide the groundwork for future immune-based therapies and vaccination strategies. We also are studying mechanisms by which S. aureus and dysbiosis of the skin microbiome contribute to inflammatory skin diseases such as atopic dermatitis and psoriasis. Previous research experience with first-author peer-reviewed manuscripts in immunology or host-pathogen interactions research is required. Experience in bioinformatics is desired but not required. This is a unique opportunity for highly qualified and extremely motivated applicants to start their post-doctoral training in a state-of-the-art research laboratory. The start date is flexible, but we would prefer a start date prior to January 2023.

Selected publications from the Archer Laboratory:
Ravipati A, Nolan S, Alphonse M, Dikeman D, Youn C, Wang Y, Orlando N, Patrick G, Lee S, Ortines RV, Liu H, Miller RJ, Dillen CA, Marchitto M, Cai SS, Miller LS, Archer NK. IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice. Journal of Investigative Dermatology. 2021 Oct 7;. doi: 10.1016/j.jid.2021.09.012. PMID: 34626614.

Alphonse MP, Rubens JH, Ortines RV, Orlando NA, Patel AM, Dikeman D, Wang Y, Vuong I, Joyce DP, Zhang J, Mumtaz M, Liu H, Liu Q, Youn C, Patrick GJ, Ravipati A, Miller RJ, Archer NK*, Miller LS*. Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections. Science Translational Medicine. 2021 Jul 7;13(601). doi: 10.1126/scitranslmed.abe9887. PMID: 34233954.

Patrick GJ, Liu H, Alphonse MP, Dikeman DA, Youn C, Otterson JC, Wang Y, Ravipati A, Mazhar M, Denny G, Ortines RV, Zhang E, Miller RJ, Dillen CA, Liu Q, Nolan SJ, Nguyen K, Marcello L, Do DC, Wier EM, Zhang Y, Caviness G, Klimowicz AC, Mierz DV, Fine JS, Sun G, Goldbach-Mansky R, Marusina AI, Merleev AA, Maverakis E, Garza LA, Milner JD, Gao P, Ramanujam M, Raymond EL, Archer NK*, Miller LS*. Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease. Journal of Clinical Investigation. 2021 Mar 1;131(5). doi: 10.1172/JCI143334. PMID: 33645549.

Archer NK, Jo JH, Lee SK, Kim D, Smith B, Ortines RV, Wang Y, Marchitto MC, Ravipati A, Cai SS, Dillen CA, Liu H, Miller RJ, Ashbaugh AG, Uppal AS, Oyoshi MK, Malhotra N, Hoff S, Garza LA, Kong HH, Segre JA, Geha RS, Miller LS. Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release. Journal of Allergy and Clinical Immunology. 2019 Apr;143(4):1426-1443.e6. doi: 10.1016/j.jaci.2018.08.042. PMID: 30240702.

Complete List of Published Work: https://www.ncbi.nlm.nih.gov/myncbi/nathan.archer.1/bibliography/public/

Please send an email with your CV and contact information for 3 references to Dr. Archer at: narcher2@jhmi.edu

Thank you,
Nathan K. Archer, Ph.D. Assistant Professor of Dermatology,
Faculty Member, Cellular and Molecular Medicine (CMM) and Immunology Graduate Programs Johns Hopkins Department of Dermatology Cancer Research Building II, Suite 2M04 1550 Orleans Street Baltimore, MD 21231
Lab website: https://www.hopkinsmedicine.org/dermatology/research/basic_science/archer_lab/index.html

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