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Posted 8/8/16

University of Washington - Postdoctoral Research Fellow - Immunotherapy

Postdoctoral Fellow position is available to study correlates of immune checkpoint inhibitor responses and changes in the tumor microenvironment during immune therapy in Merkel cell carcinoma (MCC), a rare and aggressive skin cancer. The successful candidate will expand the knowledge of cancer immune correlates in MCC patients who do and do not respond to immune checkpoint therapy. This position requires a self-motivated and detail-oriented individual who is eager to engage with a multi-disciplinary team in basic and translational research. This position will serve as superb training in translational research and tumor immunology.
An MD or PhD in cancer/tumor biology or immunology is prefered but we will consider other training on a case-by-case basis. Preference will be given to applicants who have hands-on experience in tumor microenvironment, tumor immunology and/or T cell receptor biology. For more information, please see the full description and instructions for applying at: http://ap.washington.edu/ahr/academic-jobs/position/nn16972/


Posted 8/4/16
Life Scientist  (P2 – Lead Scientist)

 
Kimberly-Clark and its well-known global brands are an indispensable part of life for people in more than 175 countries. Every day, nearly a quarter of the world's population trust K-C's brands and the solutions they provide to enhance their health, hygiene and well-being. With brands such as KLEENEX®, SCOTT®, HUGGIES®, PULL-UPS®, KOTEX® and DEPEND®, Kimberly-Clark holds No. 1 or No. 2 share positions in more than 80 countries.  With a 143-year history of innovation, we believe in recruiting the best people and putting them in the right jobs so that they can do their best work. If fresh thinking and a passion to win inspire you, come Unleash Your Power at Kimberly-Clark.

Summary:

The incumbent will report to a Life Science Manager and work closely with fellow scientists and other subject matter experts to aid in the conduct of fundamental and applied skin health research.  The successful candidate will develop information to enable the identification and development of viable technology options for existing and/or new products.  The successful candidate will take utilize innovative approaches to challenges and establish creative concepts for projects with broadly defined objectives.  The position will be located at our Kimberly-Clark Research & Engineering offices in Neenah, WI.

Responsibilities:
 

  • Contribute as a team member on large projects and/or lead smaller skin research programs in Corporate Research & Engineering’s Life Science organization.
  • Collaborate with technical and business leaders, internal and/or external subject matter experts, to conduct basic and applied research that delivers meaningful skin care technologies that enable business and brand aspirations.
  • Capable of translating fundamental science and technology through a progression of literature research, robust in vitro screening, and in vivo studies.
  • Maintain laboratory records sufficient to document findings and procure intellectual property for discoveries.
  • Protect and promote technologies and products through appropriate use of patents, internal and external publications, conference presentations, and trade secrets.

     
Required Qualifications:
 
  • Ph.D. in Molecular, Skin, Cell Biology or Biomedical Engineering (BME must have cell biology/tissue culture experience) with at least two years of industrial R&D experience.
  • Ability to maintain a safety culture appropriate for a biological laboratory setting.
  • Expert level experience in lab techniques to include: Nucleic acid isolation, quantitative mRNA analysis (qRT-PCR), flow cytometry, signal transduction mechanisms, microarrays, and high throughput genomic analyses.
  • Familiarity with emerging techniques in bioinformatics to inform research efforts.
  • Knowledge of epithelial cell biology and experience with primary cell culture techniques including media development, co-cultures, and in vitro tissue constructs.
  • Experienced in the conduct of in vivo clinical research for the development of fundamental information and the evaluation of emerging skin care technologies.
  • Evidence of successfully developing and leveraging novel methods, attaining protocol standardization, and performing robust data analysis to deliver results.
  • History of successful collaboration with other researchers for the conduct of in vitro and in vivo studies.
  • Excellent written communications skills as demonstrated by meaningful peer-reviewed research publications.
  • Excellent oral communication skills, well-tailored for diverse audiences, a history of meaningful conference/society presentations, seminars, and posters.
  • Proven record of successful results working in multi-disciplinary, cross-functional teams
  • Travel up to 25% (domestic and international).
 
Preferred Qualifications:
 
  • Post-doctoral experience
  • Experience with technology and patent landscape surveys
  • Evidence of coaching and mentoring other scientists
  • Project management experience
  • Language skills beyond English are highly valued.
 Contact julia.jordan@kcc.com
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Posted 7/20/16

Postdoctoral Position in Skin Cancer

Penn State Institutes of Energy and the Environment is seeking a postdoctoral researcher for a NIH funded postdoctoral position available starting September 1, 2016 in the Center for Molecular Toxicology and Carcinogenesis, Laboratory of Dr. Adam Glick http://vbs.psu.edu/research/labs/glick. This position will focus on using mouse models of epithelial cancer including the skin to study the role of ER stress in the initial stages of cancer development and progression. Specifically the project will focus on the role of IRE1a and its downstream targets in the cellular response to oncogenic Ras. Applicants should have a Ph.D. in some aspect of Cancer Biology with expertise in molecular biology, animal models and cell biology of cancer and skin cancer. Ability/eligibility to apply for own funding is expected and encouraged. To apply, please upload a letter of interest describing current research and expertise along with C.V. This is a fixed-term appointment funded for one year from date of hire with the possibility of re-funding. Apply at:https://psu.jobs/job/64228

CAMPUS SECURITY CRIME STATISTICS: For more about safety at Penn State, and to review the Annual Security Report which contains information about crime statistics and other safety and security matters, please go to  http://www.police.psu.edu/clery/ , which will also provide you with detail on how to request a hard copy of the Annual Security Report.

Penn State is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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Posted 4/29/16
Univeristy of Pittsburgh: Postdoctoral Associate
A NIH funded research laboratory (PI: Daniel H. Kaplan MD, PhD) in the Departments of Dermatology and Immunology at the University of Pittsburgh is seeking a highly motivated, energetic, research-oriented individual at the postdoctoral level.  The interest of the lab is to study the basic immunology of the skin with a particular focus on the development of innate and adaptive responses to pathogens as well as the function of non-hematopoietic cells (e.g. peripheral nerves and keratinocytes) in the development of skin immunity.  See Kashem et al Immunity 2015a (PMID: 25680275), Kashem et al Immunity 2015b (PMID: 26377898) and Mohammed et al Nature Immunology 2016 (PMID: 26901152) for details of ongoing projects. Projects are flexible but must focus on skin immunology and ideally generate the foundation for the candidate’s future independent career.  
A Ph.D. in Immunology with experience in working with mouse models, cell culture, cellular and Flow cytometry based assays is required. Experience with bioinformatics is desirable. The successful candidate will have excellent written and verbal communication skills. Eligibility to apply for NIH Training grants would also be a distinct advantage
 
It is the policy of the University of Pittsburgh School of Medicine to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity, or veteran status. Rank and salary are negotiable.  Interested candidates should send a letter of interest, CV, and names and addresses of three references to:
 
Dr. Daniel H. Kaplan, Associate Professor
Department of Dermatology, University of Pittsburgh
200 Lothrop Street; Biomedical Science Tower E1057, Pittsburgh, PA  15261
DANKAPLAN@PITT.EDU
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Senior Scientist ¡V Research Science Req. 160000G6 As a Senior Scientist ¡V Research Science, the incumbent will report to a Life Science Manager in Kimberly-Clark¡¦s Corporate Research and Engineering organization. The successful candidate will work closely with cross functional teams that include fellow scientists, business stakeholders, and other internal and external technical subject matter experts to conduct fundamental skin research. This individual will use the results attained to identify, develop, and recommend technology options that enable revenue and margin growth for existing and/or new products. Accordingly, the expectation is that this scientist will conceive and utilize innovative approaches to address business and technical challenges and establish research projects within broadly defined objectives. The position will be located at our Research & Engineering facility in Neenah, WI.
Responsibilities:
  • Contribute as a team member on large projects and/or lead smaller skin/vaginal research programs in Corporate Research & Engineerings Life Science organization.
  • Collaborate with technical and business leaders, internal and/or external subject matter experts, to conduct basic and applied research that delivers meaningful skin and/or vaginal health technologies that enable business aspirations.
  • Capable of translating fundamental science and technology through a progression of literature, robust in vitro screening, to in vivo clinical research. 
  • Establish and maintain relevant academic and vendor partnerships.
  • Operate and maintain flow cytometer. „h Protect and promote technologies and products through appropriate use of patents, internal and external publications, conference presentations, and trade secrets. „h Maintain laboratory records sufficient to document findings and procure intellectual property for discoveries.


Basic Qualifications:
  • Ph.D. in Immunology. „h Minimum 7-10 years of experience required.
  • Ability to maintain a safety culture appropriate for a biological laboratory setting.
  • Comprehensive knowledge of epidermal immunology and cell biology as it relates to both acute and chronic inflammation such as contact irritant and atopic dermatitis.
  • Expert level laboratory techniques including: mammalian cell culture, co-culture, qRT-PCR, immunohistochemistry, flow cytometry, microscopy, histology, immunoblotting, signal transduction, and high throughput automation for small molecule discovery.
  • Capable of developing and leveraging in vitro and ex vivo living skin models and isolating cells from tissue explants.
  • Familiarity with emerging techniques in bioinformatics to inform research efforts.
  • Evidence of developing and leveraging novel methods, attaining protocol standardization, and performing robust data analysis to deliver results.
  • History of successful collaboration with other researchers for the conduct of in vitro and in vivo studies.
  • Excellent written communications skills as demonstrated by meaningful peer-reviewed research publications.
  • Excellent oral communication skills, well-tailored for diverse audiences, a history of meaningful conference/society presentations, seminars, and posters.
  • Proven record of successful results attained by working in a multi-disciplinary, cross-functional environment within an industrial research setting.
  • Travel up to 25% (domestic and international).


Preferred Qualifications:
  • Relevant post-doctoral experience.
  • Neonatal/Pediatric dermatology expertise.
  • Evidence of coaching and mentoring other scientists.
  • Project management experience.
  • Language skills beyond English are highly valued.
Kimberly-Clark and its well-known global brands are an indispensable part of life for people in more than 175 countries. Every day, 1.3 billion people - nearly a quarter of the world's population - trust K-C brands and the solutions they provide to enhance their health, hygiene, and well-being. With brands such as Kleenex, Scott, Huggies, Pull-Ups, Kotex, and Depend, Kimberly-Clark holds No.1 or No. 2 share positions in more than 80 countries. With more than 140 years of history of innovation, we believe in recruiting the best people and empowering them do their best work. If fresh thinking and a passion to win inspire you, come Unleash Your Power at Kimberly-Clark. Kimberly-Clark is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, sexual orientation, gender identity or any other characteristic protected by law. The statements above are intended to describe the general nature and level of work performed by employees assigned to this classification. Statements are not intended to be construed as an exhaustive list of all duties, responsibilities and skills required for this position

Contact Julia.jordan@kcc.com
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Posted 1/26/16

3 years at Nottingham and chance to meet Robin Hood!


The University of Nottingham School of Medicine – Centre of Evidence Based Dermatology
 
PhD Studentship
 
Validating the Patient Orientated Eczema Measure (POEM) for inclusion in the core outcome set for eczema trials
Principal supervisor: Professor Kim Thomas
Other supervisors: Dr Sonia Ratib
Applications are invited for a prestigious British Skin Foundation PhD studentship (three-years full-time) within the Centre of Evidence Based Dermatology at the University of Nottingham.
The Centre of Evidence Based Dermatology (CEBD)
The CEBD has an international reputation for independent research into the prevention and treatment of skin disease.  It is the editorial base for the Cochrane Skin Group and the co-ordinating centre for the UK Dermatology Clinical Trials Network.   The Centre includes a number of research scientists and PhD students with expertise in systematic reviewing, the design and conduct of clinical trials, disease definition, consensus methodology, patient involvement and outcomes research.  The group attracts around £1 million of grant income per year with a focus on delivering independent clinical research that informs the NHS. For further information visit: www.nottingham.ac.uk/dermatology.
The project
Over 600 randomised controlled trials (RCTs) have been published on treatments for eczema. Several types of treatment are available and they are generally aimed at symptom relief. One of the main limiting factors in pooling data from multiple RCTs and conducting meta-analyses is the variation in outcome measures selected to capture treatment effects, and differences in how and when these outcomes are measured. The Patient Orientated Eczema Measure (POEM) scale is recommended by the National Institute for Health and Care Excellence (NICE) and was recently selected by the international Harmonizing Outcome Measures for Eczema (HOME) initiative as the preferred instrument for measuring eczema symptoms in the core outcome set for eczema trials. HOME is a global collaborative network of over 200 people (including patients, clinicians, pharmaceutical industry representatives and regulators). For more information about HOME please see: http://www.nottingham.ac.uk/homeforeczema/index.aspx
A core outcome set is an essential set of outcomes that are recommended for collection in all future trials for a given condition (http://www.comet-initiative.org/about/overview). By defining a core outcome set, results from different trials can be compared more easily and the quality of trials can be improved. Better quality trials will mean better outcomes for patients.
 
Although the POEM scale is one of the best validated scales for the measurement of eczema symptoms, some areas remain uncertain. The proposed series of linked studies, which make up this PhD, will address these uncertainties.
 
Project objectives
This project will use existing datasets from five UK-funded eczema trials to address known validation gaps:
  1. What is the structural validity of POEM and would inclusion of additional items improve performance of the scale?
  2. Should intensity of symptoms be captured in addition to frequency of symptoms?
  3. Is repeated measurement of POEM a useful way of measuring long-term control?
  4. What is the minimum clinically important difference for POEM in different trial settings and populations?
  5. What is the cross-cultural validity of POEM?
  This project would give the successful applicant the opportunity to learn skills in:
  • Conducting systematic reviews
  • Development of outcome scales for use in clinical research
  • Testing psychometric properties of scales
  • Designing and conducting studies to evaluate psychometric properties (including qualitative and quantitative studies)
  • Statistical techniques
  • Consensus methodology
  • Patient and public involvement
     
    The student will have an opportunity to work alongside international members of the HOME initiative and present findings at both national and international conferences. It is expected that the student will write at least four papers for peer-reviewed journals.
     
    The HOME initiative has a membership of over 200 people, and this network will ensure rapid global dissemination of your findings.
Further Information
Applicants must have at a minimum of a UK 2.1 degree (or equivalent) in a relevant discipline. It is desirable that they have a MSc in Medical Statistics, Psychology, Epidemiology, Public Health or a related area with very good results, excellent quantitative skills, practical experience of analysing data with a meticulous approach and an interest in eczema. Prior experience of using repeated measures data, multi-level modelling and/or scale development will be advantageous. Informal enquiries may be addressed to Prof Kim Thomas (kim.thomas@nottingham.ac.uk).
The studentship will include the payment of tuition fees at the Home/EU rate and a maintenance stipend at current RCUK levels (£14,057 for 2015/16, updated each year). Non-EU students are welcome, but they would have to self-fund the difference between the Home/EU (£3,996) and international fee (£13,470).
The University of Nottingham is the top 1% of global universities and is ranked eighth in the UK on a measure of ‘research power’, with more than 80% of research rated as world-leading or internationally excellent. The University of Nottingham also offers a world-class research training environment for postgraduate students, including an excellent range of support and services.
To apply, students should send a CV, cover letter explaining why they would like the opportunity to study for this PhD, when they are available to start their studies, and details of two referees to Prof Kim Thomas (kim.thomas@nottingham.ac.uk).
Please quote ref: Closing date: Advertised until filled.
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Posted 1/22/16
Postdoctoral position, Cutaneous Biology Research Center, Harvard Medical School.
 
Postdoctoral position to study organogenesis and regeneration using the mouse hair follicle as a model system. The Morgan lab exploits genetically engineered mice to study the role of the mesenchyme in the development and regeneration of the hair follicle with a focus on how feedback between the epithelial and mesenchymal compartments is modified to regulate regeneration and to achieve distinct morphogenetic outcomes. Preference will be given to recent Ph.D. graduates with a strong background in developmental or stem cell biology and molecular biology skills. To apply, send a c.v. and statement of research interest to Bruce Morgan <bmorgan@mgh.harvard.edu>.

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Posted January 7, 2016

Exciting postdoctoral fellowship position open now in the well-funded laboratory of Dr. Amy Paller, Chair of the Department of Dermatology at Northwestern University, to study the application of nanotechnology in the treatment of skin diseases. Enthusiastic candidates must have PhD or MD with previous bench experience. Fellowship provides exposure to molecular and cell biology, in vivo application, and cutting-edge nanotechnology. Dr. Paller is also Principal Investigator of the NIH-funded Skin Disease Research Center and is active in Northwestern's International Institute for Nanotechnology. Salary and benefits are competitive. Interested applicants can send CVs and letter of interest to Geoff White: g-white@northwestern.edu


Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women and minorities are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
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